Daddy Yankee entered into a strategic global partnership with Universal Music Group in September 2020, which involves the release of new music and film projects.

Daddy Yankee starred in the 'Infinite Summer' campaign for Puerto Rico Tourism Company in July 2024, promoting the island as an ideal year-round vacation destination. His song 'Bonita' was used as the campaign's soundtrack.

Daddy Yankee signed with HYBE Latin America in July 2025, marking his return to music after a brief retirement. He celebrated this partnership by releasing a new single, 'Sonríele,' on the same day as the announcement.

Daddy Yankee's music publishing and master recording catalog was acquired by Concord in October 2024. This acquisition includes key hits like 'Gasolina,' 'Con Calma,' and 'Despacito,' as well as certain name, image, and likeness rights.

Daddy Yankee partnered with Zumba in March 2017 to promote his single 'Hula Hoop.' This collaboration included the creation of official Zumba choreography for the song, which was shared on the artist's social media platforms.

Daddy Yankee signed a multi-year deal with Reebok in 2005, which included the launch of a signature collection called 'DY' featuring athletic footwear, apparel, and accessories. The products were set to debut the following spring at athletic specialty retailers.