Lupita Nyong'o was featured alongside Saoirse Ronan in the 2018 campaign for Calvin Klein's 'Women' fragrance, directed by artist Anne Collier and emphasizing the brand's focus on femininity and empowerment.

Lupita Nyong'o joined Chanel as a global brand ambassador in 2024, attending events such as the pre-fall 2025 show in Hangzhou, China, where she expressed the significance of realizing a dream of Mademoiselle Chanel's.

Lupita Nyong'o was appointed as De Beers' first global ambassador in 2024, starring in the 'Where It Begins' campaign. This role also supports the brand's Building Forever project, which aims to engage 10,000 girls in STEM and invest at least $10 million across southern Africa by 2030.