Naomi Osaka launched the Victoria's Secret x Naomi Osaka design collaboration in February 2023, marking the brand's first partnership with an individual collaborator in its 45-year history. The collection includes casual sleepwear and intimates, inspired by self-love and the beauty of dreaming.

Naomi Osaka was announced as a brand ambassador for Louis Vuitton in January 2021, featuring prominently in the brand's Spring-Summer 2021 campaign, which was photographed by creative director Nicolas Ghesquière.

Naomi Osaka became the first global ambassador for Maybelline New York's Brave Together program in October 2024, focusing on mental health awareness and support. This initiative aims to provide accessible one-to-one support for anxiety and depression and seeks to destigmatize mental health conversations.