Francis Ngannou became the first partner in Jellysmack's Marquee Program, which focuses on helping prominent public personalities develop and enhance their social presence and revenue generation across multiple social media platforms.

Francis Ngannou partnered with Soul Machines in October 2023 to create 'Digital Francis,' an AI-powered digital twin that enhances fan engagement. This collaboration aims to bring the experiences of the heavyweight champion closer to his fans.

Francis Ngannou became the Pan-African Brand Ambassador for Premier Bet in July 2025. He features in their marketing campaigns, promotional activities, and CSR projects, while also promoting responsible gambling and participating in exclusive events.

Francis Ngannou has an exclusive global MMA strategic partnership with Professional Fighters League (PFL), which was announced in May 2023. He competes in PFL's PPV Super Fight Division and serves as Chairman and minority equity owner of PFL Africa, in addition to being a member of the PFL Global Athlete Advisory Board.