Khaby Lame became a global ambassador for Binance, where he is involved in a series of educational videos alongside F1 superstar Pierre Gasly. These videos aim to simplify blockchain technology concepts for a general audience, making them more accessible to people unfamiliar with Web3.

Khaby Lame partnered with Rich Sparkle Holdings Ltd. in January 2026, entering into a $975 million deal that gives Rich Sparkle exclusive global rights to his brand for 36 months. This partnership aims to leverage Lame's 360 million social-media followers and includes the development of an AI 'digital twin' using his biometric data to automate and scale content production worldwide.

Khaby Lame stars in the unscripted series 'Khaby Is Coming To America,' which premiered on Tubi on June 27, 2024. The series, backed by Procter & Gamble, showcases Khaby as he explores the best and weirdest aspects of American culture. It was created in partnership with Group Black and features integrated P&G brands such as Tide, Crest, Febreze, and Bevel.

Khaby Lame was appointed as the Official FIFA World Cup Qatar 2022™ Brand Ambassador for QNB Group. In this role, he launched his first-ever television commercial with the bank, which explores the theme of 'dreaming big.' The announcement was made during an official signing ceremony that included key executives from QNB Group.

Khaby Lame was officially introduced as a playable 'Icon Series' skin in Epic Games' popular battle royale game Fortnite in August 2023. This collaboration included a digital recreation of his likeness, a 'Point & Shoot' emote, and a 'Silent Slicer' pickaxe, enhancing the gaming experience for players.